Please check with your local Nikon support representative for system compatibility.
There also may be geographical differences in device support.

Nikon Devices & Cameras

Microscopes and Accessories

  • ECLIPSE Ni-E, Ni-U
  • ECLIPSE LV150 Series, LV100D, LV100 POL
    • All Nikon motorized components (FMA, Episcopic Illuminator, Nosepiece, etc.)
    • All Nikon motorized components (Focus, XY Stage, ND Filter Unit, Nosepiece, Condenser, Field Diaphragm, etc.)
  • Stereomicroscope SMZ25, SMZ18, SMZ1270i, SMZ1270
  • Nikon AZ100/AZ00M
  • Illumination: Intensilight E
  • Nikon DUV-B Tunable GaAsP Detector for A1 and C2si-R
  • Nikon LU-NV, LU-N4, LU-NF Laser Units
  • Nikon Ti-LAPP DMD (digital mirror device)
  • Mightex Polygon 400 dynamic spatial light modulator
  • Bruker XY Miniscanner
  • Nikon AX, AX R
  • Nikon A1 HD25, A1R HD25, A1/A1R, A1R HD MP, A1 MP+, A1R MP+
  • Nikon C2+
  • Nikon N-SIM Structured Illumination
  • Nikon N-STORM Super-Resolution
  • Nikon Ti-LAPP HTIRF
  • Yokogawa CSU-X1, W1
  • CrEST XLight Spinning disk
  • ECLIPSE i-Series 90i (Legacy)
  • ECLIPSE TE2000E, TE2000E2, TE2000-PFS (Perfect Focus System) (Legacy)
  • Digital Imaging Heads (DDH-E (motorized) and D-DH-M) (Legacy)
  • Keysight 4 Line Monolithic Laser Module (USA and Europe Only) (Legacy)

Cameras and Controllers

  • Digital Sight Cameras: DS1000, DS10, DS50M, DS-Fi3, DS-Ri2, DS-Qi2, DS-Fi2 (U3, L3) DS-Fi1 (U2, U3, L2, L3), DS-Ri1 (U2, U3, L2, L3), DS-Qi1 (U2, U3, L2, L3), DS-Vi1 (U2, U3, L2, L3)
  • Digital Sight Cameras: DS-2Mv, DS-2MBW, DS-2MBWc, DS-1QM, DS-Ri1, DS-Qi
  • DS-2Mv(U2), DS-2MBW, DS-2MBWc, DS-5M (U2), DS-5Mc (U2)
  • Controllers: U3, L4, L3, L2 (Legacy), U2 (Legacy)

Other Cameras & Devices

Some models may not be supported by NIS-Elements. Please contact Nikon for details.


  • Photometrics CoolSnap Dyno, Evolve Series, Prime 95B, Prime 95B 25mm, Prime 95B 22mm, IRIS
  • Lumenera 1-2CB and 1-3C
  • Hamamatsu ORCA ER Firewire Camera, C9100-12, C9100-13, R2, ORCA-Flash2.8, Orca-Flash4.0, Orca-Flash LT, ORCA D2, ImagEM, ImagEM-1K, ImageEM2
  • Andor Neo sCMOS, DU-888, Zyla 5.5 and 4.2 sCMOS (Zyla via USB3) iXon X3, iXon+ (models 897, 888, 885,860), iXonEM, iKon-M, Clara, Luca S, Luca R
  • Imaging Source Cameras
  • PCO Cameras - pco.edge 4.2, pco.edge 5.5, pco.edge 4.2 LT, pco.edge 3.1, pco.edge gold 4.2, pco.edge gold 5.5
  • QImaging Retiga R1 (mono)


  • Stages
    • Prior ProScan II, ProScan III, OptiScan III, ES10ZE, Z-Deck
    • Applied Scientific Instrumentation (ASI) MS-2000
    • Ludl MAC 5000 / MAC 6000 Controller
    • Märzhäuser: Tango, LSTEP, ECO-STEP
    • Scientifica XY Linear Stage
  • Filter Wheels
    • Prior Filter Wheel System
    • Sutter Wheels, Shutters, Controllers: Lambda 10-2, 10-3, 10-B
    • Applied Scientific Instrumentation (ASI) FW-2000
    • Ludl MAC 6000 Controller
    • Finger Lake Instrumentation Filter Wheel (USA Only)
    • Crest Optics Filter Wheel
  • Wavelength Switching/ Excitation System
    • Sutter DG 4 / DG 5 (Ultra-High Speed Wavelength Switcher)
    • Nikon LUSU (Laser / Shutter Unit)
    • Lumencor Spectra, SpectraX, Aura, AuraII, LIDA
    • 89North Heliophor
    • CoolLED pE-300ultra, pE-340fura, pE-4000
  • Shutter Control
    • Uniblitz Shutter Controller VCM-D1
    • Sutter: Smart Shutter Standalone Controller Lambda SC
    • Applied Scientific Instrumentation (ASI) SC-2000
    • Ludl MAC 6000 Controller
  • Z Motors
    • Nikon Motorized Z-Focus Accessory (RFA)
    • Prior Z-motor, ES10ZE, NIKRFK
    • Applied Scientific Instrumentation (ASI) MS-2000
    • Physik Instrumente Piezo E-665 (RS232)
    • All Piezo devices accepting analog voltage input
    • MCL Nanodrive
    • Physik Instrumente E-545, 662, 665, 712, 861, 867 piezo controllers
  • Camera Emission Splitters
    • Optical Insights Dual View, Quad View
    • Cairn Research Optosplit II, Optosplit III, Multisplit V2, TwinCam, MultiCam
  • Illumination
    • Excelitas (Lumen Dynamics) X-Cite120, X-Cite LED1, X-Cite LED120, X-Cite exacte, X-Cite TURBO
    • Lumencor Sola, Sola II
    • Prior Lumen Pro
    • Sutter Lambda XL
    • CoolLED pE-300white, pE-300ultra, pE-340fura, pE-100, pT-100, pE-4000
    • LCI Touch Bright
  • High Speed I/O
    • National Instruments DAQm series controllers (PCI, PCIe, and PXI formats) e.g. NI6723, 6353, 6221, 6733, 6713, 6711, 6229
  • Heating Controllers
    • Linkam TP 95, 94, 93, 92
  • Incubators
    • OKOLab Microscope Incubators
    • Tokai Hit Microscope Incubators
    • LCI CU-501 Controller (LCI Chamlide)
    • Life Imaging Services (LIS) Cube & Brick

Please check with your local Nikon support representative for system compatibility.
There also may be geographical differences in device support.

Operating Environment

Operating System

  • Windows 10 64-bit Professional(Ar, Br, D, C & F)
    *Note: NIS-Elements cannot be installed on Windows XP Operating Systems. Enterprise is not supported or recommended.

*Nikon will provide Legacy support for certain camera and devices. This support is limited and additional development or changes to the drivers is not available.