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A step up in digital pathology using innovative digital microscopy.
Kitasato University Kitasato Institute Hospital
Director, Department of Pathology
Dr. Ichiro Maeda
Currently there are various treatment methods under development that could provide optimal medical care in response to the pathological attributes of each patient. Therefore, the role required of pathological diagnosis, which is indispensable for the planning of treatment policies and strategies, is becoming more important than ever before. However, the shortage of trained pathologists who assume this role is a common issue, not only in Japan, but also worldwide. To solve this problem, digital pathology has been attracting attention. In this article, we asked Dr. Ichiro Maeda, Director of the Department of Pathology, Kitasato University Kitasato Institute Hospital, for his impressions of using the digital image display optical microscope "ECLIPSE Ui".
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"In vitro fertilization is a race against time. I thought this microscope was very helpful in that sense."
In April 2022, insurance coverage for infertility treatment started in Japan, making it easier for couples who want to conceive to receive ICSI treatment. However, in general, there is still a belief that “infertility is not a disease”, so there are many patients who suffer from anxiety or feel impatient during treatment. We interviewed Shoko Ieda and Sumi Shimamura of the Minatomirai Yume Clinic, who say that they find it rewarding to acknowledge these emotions and help such patients with the birth of their babies, about their impressions of using “ECLIPSE Ti2-I”.
*Customers have provided feedback to Nikon on this microscope’s features and clinical usefulness, based on their own personal experience
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YOUR SWITCH TO THE FUTURE
Cincinnati Children’s Hospital Medical Center
Matthew Kofron, Ph.D.
Professor, UC Department of Pediatrics
Alicia Ostmann
Cincinnati Cystic Fibrosis Theratyping Research Center
Kentaro Iwasawa, M.D.
Takebe Lab, Division of Gastroenterology
Research Outline: Child health improvement. Organoid creation. Drug efficacy for cystic fibrosis patients.
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YOUR SWITCH TO THE FUTURE
European Institute for Molecular Imaging (EIMI)
Professor Friedmann Kiefer, Ph.D.
Department of Intravital Molecular Imaging
Research Outline: Elucidation of how molecular mechanisms shape human cells and tissues biologically. Multiscale imaging.
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YOUR SWITCH TO THE FUTURE
National Institutes of Natural Sciences, National Institute for Physiological Sciences
Tetsuhisa Otani, Ph.D. Assistant Professor
Division of Cell Structure
Research Outline: Epithelial tissue.
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YOUR SWITCH TO THE FUTURE
Korea Advanced Institute of Science and Technology
Professor Won Do Heo, Ph.D.
Department of Biological Sciences
Research Outline: Optogenetic and bio-imaging technologies.
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YOUR SWITCH TO THE FUTURE
Chinese Institute for Brain Research, Beijing, China
Dr. Hu Zhao, Principal Investigator
Research Outline: New tissue clearing methods, and building a neural connectome mapping platform based on these methods.
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“I believe this can change conventional imaging for pathologists”
Takeshi Sasaki
Professor, Project Leader, M.D. Ph.D
The University of Tokyo Hospital
Dept. of Next-Generation Pathology Information Networking
In medicine, pathologists play an extremely important role in confirming observation. They are often making observations with a microscope for long periods of time and the physical and mental burden of this is heavy. Aiming to reduce such stress issues for pathologists, Nikon has developed a new microscope for pathological examination, the ECLIPSE Ui, which allows pathologists to view high-resolution images of specimens on a monitor, rather than looking through eyepieces. Here, Dr. Takeshi Sasaki of the University of Tokyo Hospital, who has evaluated this microscope, talks about his impressions of it.
*Dr. Sasaki has provided feedback to Nikon on this microscope’s features and clinical usefulness based on his own personal experience.
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Nikon BioImaging Lab contributes to “mini-gut” research
Dr. Hidenori Akutsu
Director of the Department of Reproductive Medicine, Center for Regenerative Medicine, National Center for Child Health and Development
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Nikon Equipment and Services
YOUR SWITCH TO THE FUTURE
Research Institute for Microbial Diseases (RIMD) at Osaka University
Hiroaki Miki, Professor
Yosuke Funato, Associate Professor
Osamu Hashizume, Assistant Professor
Division of Cellular and Molecular Biology, Department of Cellular Regulation
Research Outline: Analyzing the function of a membrane protein molecule called Cyclin M, which plays a role in ejecting magnesium ions from cells.
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Supporting classroom studies with the ECLIPSE Ei
“It’s easy to teach the students how to use it, and they find it simple to use as well”
Observation utilizing microscopes plays an extremely important role in learning the basics of science. Nikon’s ECLIPSE Ei was developed as an educational-use microscope with the concept of being a ‘user-friendly microscope even for students operating it for the first time’. We visited Ms. Rika Izumi, a science teacher at Rikkyo Niiza Junior and Senior High School, Saitama, Japan, where the ECLIPSE Ei is available in the classrooms, to learn about the background and reasons for choosing this microscope, the user experience, and the reactions from students.
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The ECLIPSE Ci-L plus contributes to more comfortable clinical examinations.
“Together with the high optical performance, I realized its thoughtful design aids our daily work.”
Clinical examinations play an important role in medical care. Nikon has developed a new biological microscope, the ECLIPSE Ci-L plus, with the concept of reducing physical and mental strain on clinicians and laboratory technicians who use microscopes on a daily basis. In this interview, we talked to Dr. Akira Yoshikawa from the Department of Anatomic Pathology, Kameda Medical Center – a flagship hospital in the southern part of Chiba prefecture, Japan – on his thoughts after employing this microscope and the newly developed objective lens for microscopes ‘CFI Plan Apochromat Lambda D’ for practical everyday use.
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Associate Prof. Dr. Klazina Kooiman and Dr. Ines Beekers
Associate Prof. Dr. Klazina Kooiman, Head of Therapeutic Ultrasound Contrast Agent Group, and Dr. Ines Beekers, Postdoctoral Researcher in the Department of Biomedical Engineering of the Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands
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Reproduction Clinic Tokyo
“Finding the best sperm among the millions. For embryologists, this is the unique work of selection, and we feel a great sense of responsibility.”
Reproduction Clinic Tokyo, a fertility clinic located on the third floor of Shiodome City Center, a state-of-the-art office building in the Shiodome area of central Tokyo, has a large number of patients waiting for treatment, even in the evening on weekdays. We spoke with Shimpei Mizuta and Tomohiro Maekawa, who are using Nikon’s Ti2 inverted microscope for sperm sorting and Intracytoplasmic Sperm Injection (ICSI), about their thoughts on their work and their impressions of the Ti2.
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Dr. Yohei Yamauchi
Dr. Yohei Yamauchi, Principal Investigator, Cell biologist of viral infections, School of Cellular and Molecular Medicine, University of Bristol, UK
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Assistant Prof. Joseph Michael Hyser & Dr. Alexandra Leigh Chang-Graham
Virology and Microbiology
Baylor College of Medicine
Houston, Texas, USA
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Assistant Prof. Klazina Kooiman & Inés Beekers
Therapeutic Ultrasound Contrast Agent Group, Thoraxcenter, Department of Biomedical Engineering, Erasmus MC, Rotterdam
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Prof. Wendy Bickmore
Director: MRC Human Genetics Unit, University of Edinburgh
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Dr. Steven Nedellec and Dr. Tiphaine Douanne
Dr. Steven Nedellec, Facility Manager of MicroPICell, Université de Nantes, France and Dr. Tiphaine Douanne, Universite de Nantes, Signaling in Oncogenesis, Angiogenesis and Permeability, CRCINA INSERM U1232, France
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Dr. Steve Thomas
Senior Lecturer in Cardiovascular Science, University of Birmingham
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Dr. Tadahiro Iimura
Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University
Division of Analytical Bio-Medicine, Advanced Research Support Center (ADRES), Ehime University
Graduate School of Medicine, Ehime University
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Melike Lakadamyali, Ph.D.
The advanced Fluorescence Imaging and Biophysics Group, ICFO-Institute of Photonic Sciences
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Simon C. Watkins, Ph.D.
Professor and Vice Chairman of the Dept. of Cell Biology
Director and Founder of the Center for Biologic Imaging
University of Pittsburgh
Pittsburgh, Pennsylvania, USA
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Ronald D. Vale, Ph.D.
Professor and Vice-Chairman of the Department of Cellular and Molecular Pharmacology
Investigator, Howard Hughes Medical Institute (HHMI)
The University of California, San Francisco San Francisco, CA, USA
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Nikon Equipment
- ECLIPSE Ti-E Inverted Microscope (see current model: ECLIPSE Ti2)
- TIRF Illumination System
Tomomi Nemoto, Ph.D. and Ryosuke Kawakami, Ph.D.
Research Institute for Electronic Science
Sapporo, Hokkaido, Japan
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Tamas Freund, Ph.D. and Istvan Katona, Ph.D.
Institute of Experimental Medicine of the Hungarian Academy of Sciences (IEM HAS)
Budapest, Hungary
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Maddy Parsons, Ph.D.
Group Leader (Royal Society University Research Fellow)
Randall Division of Cell and Molecular Biophysics
King’s College London
London, United Kingdom
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Nikon Equipment
- A1Rsi Confocal (see current model: AX/AX R)
- A1R-TIRF Confocal (see current model: AX/AX R)
Alberto Diaspro, Ph.D.
Professor of Applied Physics, Department of Physics, University of Genoa
Director of the Department of Nanophysics, Istituto Italiano di Tecnologia
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Paul Ronald Selvin, Ph.D.
Professor, Department of Physics, University of Illinois at Urbana-Champaign
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Nikon Equipment
- ECLIPSE Ti-E Inverted Microscope (see current model: ECLIPSE Ti2)
Bo Huang, Ph.D.
Assistant Professor, Department of Pharmaceutical Chemistry, Department of Biochemistry and Biophysics, University of California, San Francisco
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Atsushi Miyawaki, M.D., Ph.D.
Senior Team Leader, Laboratory for Cell Function Dynamics, RIKEN Brain Science Institute
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Nikon Equipment
- AZ-C1 macro confocal microscope system
- 1x objective lens (AZ-Plan Apo, NA 0.1, W.D. 35 mm)
- 2x objective lens (AZ-Plan Fluor, NA 0.2, W.D. 45 mm)
Ikuo Wada, Ph.D.
Department of Cell Science, Institute of Biomedical Science, Fukushima Medical University
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Romain Le Bars, Ph.D.
The Imagerie-Gif light microscopy core facility is a member of the France Bioimaging Infrastructure. The facility is hosted by the Institute for Integrative Biology of the Cell (I2BC) at Gif sur Yvette, France.
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Prof. Staffan Strömblad, Ph.D.
Staffan Strömblad Ph.D. is group leader at the prestigious Karolinska Institutet, Stockholm, Sweden, an institution that awards the Physiology Nobel Prize yearly. He is also the head of the Live Cell Imaging Facility (LCI), in which the Nikon Center of Excellence for live cell imaging is integrate.
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Nikon Equipment
- A1R Resonant Scanning Confocal System (see current model: AX/AX R)
- A1 Confocal Microscope System (see current model: AX/AX R)
Dr. Arne Seitz, Dr. Romain Guiet and Thierry Laroche
The Faculty of Life Science (SV) at the École Polytechnique Fédéral de Laussane (EPFL), Switzerland, has a long record of excellence in research applied to life sciences
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Dr. Jacopo Lucci
Chief Scientific Officer at Natural Bio-Medicine SpA,
Aboca Group
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Masato Nakagawa
So-called iPS cells are attracting considerable interest as pluripotent stem cells that may open up a whole new world of medicine. The Center for iPS Cell Research and Application (CiRA) at Kyoto University is pursuing a wide range of research activities that aim to realize regenerative medicine utilizing iPS cells. The Nikon BioStation CT cell culture observation system is being used in this iPS cell research and is contributing to its efficiency.
We were pleased to have had an opportunity to speak with Masato Nakagawa, who is engaged in iPS cell research at CiRA.
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Prof. Heinz Beck, Ph.D.
Full time professor at the Laboratory of Experimental Epileptology and Cognition Research hosted in the Life & Brain Center, Part of the University of Bonn.
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