Application Notes
Precision Imaging in Complex Tissue Structures
Efficient Whole-Tissue Overview and Sub-Micron Imaging with the AXR NSPARC Super-Resolution Confocal System
December 2024
One of the primary functions of the kidneys is to filter waste products and salts from the blood, expelling them through urine. This task is carried out by the glomerulus, a specialized structure within the kidney. The glomerulus’ intricate, sieve-like architecture plays a vital role in selectively filtering blood as it flows through the kidney. In this application note, we demonstrate how Nikon’s advanced AXR NSPARC confocal microscope enables the efficient study of the three-dimensional structure of the mouse glomerulus. This system facilitates the quick identification of target regions and the capture of high-resolution images of sub-micron structures, even within complex tissue environments.
Keywords: Glomerulus, Solid-State Tissue Clearing, Polymer-Embedded Tissue, High-Speed Resonant Scanning, ISM, Airy Unit, Refractive Index