ECLIPSE Ji

Tamura: Based on technologies cultivated with inverted microscopes for research, we thoroughly discussed how to design hardware that would respond to the themes of “easy operation” using AI and “expandability” to effectively meet diverse needs. During these discussions, we decided on the optimal lighting system, observation system specifications, etc., and successfully realized our goals. A major feature is the easy operation of the SmartExperiment installed in NIS-Elements, dedicated software for Nikon, but what is particularly revolutionary about the hardware is that we created it as a box-type microscope that avoids the usual image of microscopes being difficult to operate. We also made it upgradable via attachment of additional peripheral equipment such as a confocal microscope, immersion device and incubator, which was another major feature.

Honda: The ECLIPSE Ji was designed based on new ideas, so we had to incorporate two important elements into the design: being able to answer the latest user needs and possessing the capability to be fully compatible with the field of basic research. On the other hand, it also inherited the “DNA” that the ECLIPSE series has cultivated over many years, and projects the spirit of typical Nikon microscopes via its form and usability. While studying these factors comprehensively, we aimed to embody usability that is closely aligned with the people who would utilize this product. We strongly believed that we could create an iconic design that evokes simplicity and clarity, while at the same time creating a sense of expectation, for the finished product.

Hayashi: I started the development targeting users that have little experience using a microscope. Usually when developing software for microscopes, we tend to focus on image acquisition, however, I was fully aware that what most users ideally want is data that can be obtained from images. I believe that installing AI was an effective solution for this purpose. Regarding assays for qualitative and quantitative evaluation of cells, we repeatedly verified whether they are compatible with the experiments that are actually performed by users, and designed the simple screen configuration of SmartExperiment installed in NIS-Element so that anyone using a microscope for the first time can operate it completely intuitively.

Kadoi: Since assay provides a comprehensive workflow from imaging to analyses, we thoroughly considered the types of experiments and analyses frequently performed by users, as well as our development targets. While imaging actual usage scenarios, we repeatedly performed experiments in-house. Also, we repeated study and evaluation many times in order to build an analysis algorithm that would give us the capability of obtaining targeted analysis results using the acquired images. Regarding the GUI, we thoroughly appraised ease of operation, then added icons for selecting assays, while narrowing down the text and keeping the number of items displayed to the minimum required.

Tamura: In order to achieve automation using AI, it is necessary, for example, to accurately understand and control the condition and status of the hardware. After carefully extracting the necessary elements for this purpose, we searched for a method of performing analysis stably. We also developed the optimal illumination system and optical system including an image sensor for each assay, and established the layout configuration. Over the course of this project, we worked closely with the hardware design team, software design team, product design team, etc., from the configuration and layout design stage, and proceeded with the design and development while quickly identifying any issues and solutions that could not have been predicted at the specification development stage.

Honda: In the past, matters of design were mainly concerned with appearance and screen UI, but now, the field has expanded dramatically. The biggest challenge for this project was to participate in consideration and appraisal of product concepts and specifications at the upstream stage of development, and then develop the design from there. After deepening our understanding of usage methods, user information, the market and social backgrounds, we organized and visualized the size, frame, outline and necessary components. After confirming the design sketches drawn by design and development members as well as consulting with the marketing and sales department several times, we were able to derive the optimum solution: a benchtop box style.

Hayashi: As an unprecedented initiative, we have evaluated assay, and incorporated functions that utilize AI. Speaking of the assay evaluation, conventional products have been evaluated based on accuracy and performance. However, in this case, we have defined how to use assay, then held many discussions about exactly how to evaluate it. Regarding the automation function that utilizes AI, we advanced development employing a new scheme, since the workflow is completely different from the conventional observation method using a microscope. At first glance, it seemed somewhat like a detour, but in actuality it turned out to be a valuable experience for everyone on the project team.

Kadoi: When developing an unprecedented product, it is necessary to incorporate knowledge and technology from new fields, and collaboration with many people both within and outside the company became an important issue. For example, we collaborated with Nikon Instruments Inc. in the United States to examine and share basic concepts. Furthermore, we worked together to streamline the development and implementation of analysis algorithms and made the study of assay protocols more efficient. The ECLIPSE Ji is the result of bringing together diverse knowledge, experience, and technology that transcends boundaries internally and externally of the company, as well as within Japan and internationally.

Tamura: Even people who have previously avoided using microscopes because they thought they were difficult to use can now stably obtain high-quality observation images via simple operation. In addition, by utilizing SmartExperiment, everything from cell imaging to analysis and report creation can be done automatically, allowing users to use their limited time much more effectively.

Honda: Easy operation supported by AI and versatile expandability enable many users to perform advanced observation and analysis at drug discovery facilities and basic research fields at universities, contributing to their respective operations and research. I sincerely hope that the appearance of this product becomes a symbol of that sense of trust and security.

Hayashi: I believe that the ECLIPSE Ji will inspire microscope manufacturers to shift their business model from merely providing equipment to proposing optimum imaging solutions. In addition, I hope that the spread of cell-based drug discovery screening will shorten the time and cost of drug development and thereby lead to encouraging the development of therapeutic drugs for rare diseases that have been difficult to begin dealing with in the past.

Kadoi: I am confident that the development of the ECLISE Ji has become an important foundation for Nikon to create products, technologies and services that will beneficial for society in the future as digitalization and AI proliferate widely.

I hope that the ECLIPSE Ji will continue to contribute to solving problems in drug discovery and basic research field while receiving feedback from users.

Note: The job title and responsibilities at the time of the interview.