Center of Excellence for Confocal Microscopy

Faculty of Medicine, Thammasat University

The Faculty of Medicine, Thammasat University, has partnered with Nikon, a world-leading supplier of optical instrument technology, to establish Thailand’s first Nikon Center of Excellence for Confocal Microscopy. This state-of-the-art imaging center adds next-generation light microscopy to the university's extensive research infrastructure. It bolsters not only biomedical and clinical studies but also a wide spectrum of multidisciplinary research efforts within the faculty, as well as for external researchers from other public and private institutions. It will serve as a dynamic hub for educating the broader research community on the fundamentals of microscopy and the latest advances in imaging technology.

The center features a highly advanced Nikon imaging platform, including a flagship Nikon ECLIPSE Ti2-E AX R 2K NSPARC super-resolution confocal microscope equipped with a 4-laser unit (LUD-S4) and OKO lab Bold Line live-cell capabilities on an anti-vibration platform. Additionally, the system integrates a high-resolution DS-10 camera with a high-intensity LED fluorescence light source (DLEDi). To maximize research output, the facility utilizes Nikon’s industry-leading NIS-Elements software, incorporating Enhanced Resolution (ER), High Content Analysis (HCA), and cutting-edge NIS.ai deep-learning modules for automated and intelligent image analysis.

Contact

Director

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Address

Advanced Microscopy and Imaging Center, AMIC
3rd floor, Kunakorn Building, Faculty of Medicine
Thammasat University, 99 Moo 18, Pahonyothin Rd.
Klong Nueng, Klong Luang, Pathumthani 12120, Thailand

Website

Faculty of Medicine, Thammasat University

Systems Available

AX R NSPARC Confocal Microscope System

  • Nikon AX R 2K: Equipped with a dual-scanner system featuring an 8K Galvano scanner (up to 8192 x 8192 pixels) for extreme precision and ultra-high-resolution imaging, and a 2K Resonant scanner (2048 x 2048 pixels) for incredibly fast, large-area acquisition.
  • Large Field of View (FOV 25): The AX R features an industry-leading 25 mm field of view, providing a twofold increase in imaging area compared to conventional 18 mm systems.
  • High-Speed Resonant Scanner: The resonant scanner achieves ultra-fast acquisition speeds (up to 720 fps at 2048 x 16 pixels), enabling the capture of rapid biological dynamics.
  • NSPARC Detector: An advanced array detector delivering super-resolution capabilities and a dramatically improved signal-to-noise ratio (SNR).
  • LUD-S4 (4-Laser Unit): Versatile 4-line lasers providing comprehensive wavelength coverage for multiplexed fluorescence.
  • OKO lab Bold Line Incubator: Premium stage-top system ensuring precise temperature, CO2, and O2 control for demanding live-cell experiments.
  • Anti-Vibration Table: Provides maximum mechanical stability to ensure blur-free imaging at the highest magnifications.
  • Nikon DS-10: A high-resolution microscopy camera for capturing crisp and detailed images.
  • DLEDi: A high-intensity LED light source designed for stable, efficient, and reliable fluorescence illumination.
  • NIS-Elements HCA: Streamlines high-throughput screening with automated multi-well plate acquisition and analysis workflows.
  • NIS.ai Modules: Deep-learning tools for advanced image segmentation, noise reduction, and predictive label-free imaging.