Notes d’application

Localization analysis of RNA polymerase I using a super-resolution microscope and cluster analysis function

novembre 2021

In recent years, the phenomenon of “phase separation,” by which proteins or nucleic acids compartmentalize the cells by self-assembly and control various biological functions, has been reported and is attracting attention. Structural conversion, such as relaxation and condensation of chromatin in the nucleus, and the control mechanisms of nuclear functions including gene expression, are beginning to be explained by phase separation.

This application note introduces an experimental case conducted in collaboration with Ryusuke Nozawa, Ph.D., Life Sciences, Division of Experimental Pathology, The Cancer Institute, Japanese Foundation for Cancer Research.