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Cell Observation Device

The BioStudio-T offers a unique imaging platform with a stationary sample surface and moving objective lens.  This configuration allows observation of mechanically sensitive samples, such as stem cells, with minimal perturbation.  The fixed-stage, scanning lens system also provides a superior solution for long-term time lapse imaging and large image acquisition (tiling).  Furthermore, the unique sample holder enables users to remove the sample vessel for media exchange during imaging routines without losing track of sample position. 

The Biostudio T was designed specifically for research applications in the field of regenerative medicine and stem cell biology and for use in cell manufacturing facilities.

  • Compatible with a variety of sterilization techniques:  The BioStudio-T features an exceptionally waterproof and chemical-resistant design. This easy-to-clean microscope may be sterilized using hydrogen peroxide gas and/or UV sterilization methods. The compact footprint allows for installation of the BioStudio-T in various isolators, incubators, and biosafety cabinets.
  • Unparalleled flexibility in large image acquisition:  Compatible with a variety of objective lenses (phase contrast), multi-well plates and other culture vessels.
  • Cell-friendly:  The microscope stage is completely stationary during image acquisition, eliminating unwanted mechanical disturbances to the sample.  Internal optics move to acquire images in different XY and Z positions.  A cell-friendly red LED is used for sample illumination, and only turns on during image acquisition.
  • Simple interface:  Observe results from a personal computer with a cable connection to the main body and control box.
  • Suggested applications in stem cell biology:  Observation of cell differentiation, cell division, colony formation, infiltration of cancer cells, scratch assays, and more.

Click here to find out more about a new era of cell culture with image analysis techniques


Caractéristiques-clés

High-Resolution Imaging of 2D and 3D cell cultures

Time-Lapse Imaging of MSC

High concentration (4.0x104 cells per well) of cells

Low concentration (1.0x104 cells per well) of cells

6-day time-lapse video (@6-hour intervals) of MSC growth as a function of seeding density.

Cell:Bone marrow-derived mesenchymal stem cells hTERT, PHV E7-introduced, immortalized cell line, UE7T-13 (JCRB1154, JCRB cell bank)


Time-Lapse Imaging of iPS cells

137-hour time-lapse video (40 minutes intervals) of human iPS cells using phase contrast.

Image credit: Dr. Masahiro Kino-Oka and Dr. Mee Hae Kim, Osaka University, Graduate School of Engineering, Dept. Biotech, BioProcess Systems Engineering Lab


Quickly Scan and Tile

Scan the entire cell growth surface area in a plate, dish, or flask in a matter of minutes. High contrast phase images are automatically stitched to generate high resolution data for label-free analysis.

Time-Lapse Imaging of human dermal fibroblast spheroid culture in 96-well U-bottom plates.

Stitched large image of an entire 96-well plate using 4X objective

Plates: EZ-BindShut®-SP 96well (U) plate (AGC TECHNO GLASS, catalog number: 4870-800SP), PrimeSurface® 96U plate (Sumitomo Bakelite, catalog number: MS-9096U)

Image credit: Cyfuse Biomedical K.K.