Defining Functionality in Organoids
12:00 EST / 17:00 GMT / 18:00 CET
Chief Scientific Officer, Center for Stem Cell and Organoid Medicine (CuSTOM); Cincinnati Research Foundation Endowed Professor, Division of Developmental Biology; Director for Basic Research, Division of Endocrinology; Allen Foundation Distinguished Investigator
Alysson R. Muotri
Director of the Stem Cell Program; Institute for Genomic Medicine; Dept. of Pediatrics & Cellular Molecular Medicine UCSD School of Medicine UC San Diego
Scientific Director of the Neural Stem Cell Institute Rensselaer, NY
Trends in Molecular Medicine
Organoid technology bridges preclinical and clinical science and could solve several research questions and therapeutic challenges. Stem-cell-derived organoids have been established for multiple organs and are used for human disease modeling, host-pathogen interactions, drug discovery and toxicity testing, studying organogenesis, and developing regenerative therapies. Patient-derived organoids and technological advances that allow for targeted manipulation and growing more diverse organoids have added another layer of precision. While this emphasizes their great potential in biomedical applications and precision medicine, the rapid growth of the field also highlights its lack of cohesive definitions. In light of recent scientific breakthroughs and new use cases for organoids, it is only apt that we evaluate what a functional organoid is to exploit its full potential.