Application Notes

Die optische Mikroskopie ist eine unschätzbare Technik für die biowissenschaftliche Forschung. Jeder unserer Anwendungsberichte befasst sich mit einer jeweils speziellen Forschungsaufgabe und beschreibt, wie Nikon-Mikroskopsysteme Lösungen zur Beantwortung wichtiger Forschungsfragestellungen ermöglichen.

Alle Anwendungsberichte (136)

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Quantitative, single-cell analysis of siRNA treatment using smFISH

Mai 2025

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Feedback microscopy using Nikon AX confocal microscopy and JOBS software to bridge mm to µm structures

Mai 2025

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Live-Cell Imaging of Plant Fertilization Using Nikon Multiphoton Microscope System

April 2025

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3D Imaging of Kidney Proximal Tubule Microphysiological Systems

März 2025

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Quantitative Live-Cell Imaging to Analyze Immune Cell Secretion Activity and Gene Expression

März 2025

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Speedy and clear 3D imaging of organoids

März 2025

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Imaging both H&E and immunofluorescence staining patterns on a single tissue section using the AX confocal laser microscope

März 2025

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A practical assessment of analytical performances for pseudoislet morphology by GA3 and other image analysis tools

März 2025

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High content screening of lifetime data – A feedback microscopy experiment workflow

Februar 2025

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Precision Imaging in Complex Tissue Structures

Dezember 2024

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AI-powered “Sample Navigation” simplifies image acquisition! Improved reproducibility and streamlined information sharing

November 2024

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Confocal imaging of immune cells in a vasculature network using the HUMIMIC Chip

November 2024

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3D image analysis reveals drug-induced cellular senescence and increased nucleolus volume: Efficient imaging methods to maximize data acquisition

November 2024

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High-sensitivity confocal microscope detector NSPARC enables live imaging of autophagosomes.

November 2024

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3D Confocal Imaging of Thick Samples Using Z Intensity Correction

Oktober 2024

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3D Super-Resolution Imaging of Glial Cells in Cleared Mouse Brain Tissue using NSPARC

Oktober 2024

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Image-based analysis of intracellular delivery of DNA/RNA therapeutics using NSPARC

September 2024

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Resolving subcellular detail in tissue-mimetic culture

September 2024

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The Ti2-I inverted microscope empowers microinsemination with sophisticated optical performance and operability

Juni 2024

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The mysterious and resilient creature in the moss around us, the tardigrade - Let's catch it! Let's observe it! -

Juni 2024

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The mysterious and resilient creature in the moss around us, the tardigrade - on the cutting-edge of research -

Mai 2024

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Label-free quantitative analysis of cellular senescence and high-content imaging of granules

April 2024

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High-speed, label-free THG imaging of red blood cells using a multiphoton microscope

Januar 2024

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Long-distance, rapid Ca2+ signaling in plants

Januar 2024

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Mitochondrial toxicity analysis using the AI-driven, fully automated smart imaging system ECLIPSE Ji

Januar 2024

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Calculating the percentage of cells with micronuclei using the AI-driven, fully automated smart imaging system ECLIPSE Ji

Januar 2024

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Analysis of endocytosis using the AI-driven, fully automated smart imaging system ECLIPSE Ji

Januar 2024

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Analysis of phagocytosis using the AI-driven, fully automated smart imaging system ECLIPSE Ji

Januar 2024

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Digital Staining of Mitochondria using NIS.ai and Their Importance in Drug Evaluation

Dezember 2023

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Visualization of cells cultured on cell-culture inserts and identification of cell regions through AI learning

Dezember 2023

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3D super-resolution imaging of myelin structure in human iPSC-derived myelin sheath organoids by NSPARC

Dezember 2023

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Episcopic brightfield imaging of neuronal cells on high-density microelectrode arrays enables prediction of cell region through AI learning

Dezember 2023

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Automatic isolation of pollen using NIS-Elements General Analysis (GA) and JOBS imaging workflow tools

November 2023

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Protein components of virus particles in SARS-CoV-2-infected cells imaged by N-STORM super-resolution microscope

November 2023

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SMZ25 Research Stereo Microscope for morphological research, taxonomy and type digitisation

November 2023

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Long-term, high-resolution time-lapse imaging of axon self-assembly into motor nerve organoids in a microdevice

November 2023

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A microscopy-based service for cellular signaling pathway analysis

Oktober 2023

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Improvement of ICSI Accuracy by Spindle Visualization

September 2023

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Analysis of nuclear translocation using AI-driven fully automated ECLIPSE Ji

September 2023

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Analysis of DNA Damage using AI-driven fully automated ECLIPSE Ji

September 2023

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Quantitative analysis of autophagy activity using AI-driven fully automated ECLIPSE Ji

September 2023

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Apoptosis assay using AI-driven fully automated ECLIPSE Ji

September 2023

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AI-powered optimization of transfection efficiency by nucleus and cellular region detection from brightfield images

September 2023

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Cell size and morphological analysis is easier and more comfortable with the fully automated ECLIPSE Ji

September 2023

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Pre-trained AI-powered label-free detection of cell regions from brightfield images and measurement of fluorescence intensity at the cellular level

September 2023

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Cytotoxicity assay using AI-driven, fully automated ECLIPSE Ji

September 2023

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Label-free cell counting using AI-driven fully automated smart imaging system ECLIPSE Ji

September 2023

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Super-resolution imaging of myelin in mouse brain using a multiphoton confocal microscope

August 2023

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Photostimulation time-lapse imaging of live HeLa cells using confocal microscopy

August 2023

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Diagnostic imaging of mixed connective tissue and epithelial tumors of the mammary gland by label-free imaging using multiphoton microscope

April 2023

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High-resolution macro-to-micro 3D observation of cleared rice anthers : sample preparation in view of the refractive index of immersion media

April 2023

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Confocal Imaging of in vitro BBB model using idenTx platform

April 2023

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High throughput cell proliferation assay with low magnification objective, utilizing high-resolution performance of Digital Sight 50M

März 2023

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Macroscopic and 3D imaging of small flower-like taste buds within the mouth by confocal microscopy　

März 2023

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Confocal imaging of vasculature network using the HUMIMIC Chip

März 2023

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High-content live cell imaging of ROS production in activated macrophages

März 2023

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Automatic spheroid detection and drug efficacy analysis using AX R confocal microscope

März 2023

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Macroscopic target search and high-resolution 3D imaging of gastric afferent nerve endings showing various shapes using a confocal microscope and Denoise.ai

März 2023

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Quantitative Analysis of Mitochondrial Microstructure by Super-Resolution Imaging

März 2023

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Method for selecting a phase-contrast objective for label-free visualization of spatio-temporal dynamics of cell division and organelles

März 2023

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Observation of Cell Culture Inserts Using Episcopic Brightfield Method

Februar 2023

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Membrane dynamics of recycling endosomes detected by confocal microscopy

Januar 2023

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High-speed, deep, high-resolution multiphoton imaging using expansion microscopy

Dezember 2022

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Label-Free Morphological Analysis Based on Deep Learning Using Primary Cells

Oktober 2022

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In vivo Deep Imaging of Mouse Brain using Novel Fluoropolymer Nanosheet

Oktober 2022

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Label-free detection of neuron and astrocyte regions using deep learning technology

Oktober 2022

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Mayonnaise observation and label-free analysis of oil droplet particle size distribution using AI

August 2022

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Morphogenesis of stable 3D epithelial sheet domes induced by osmotic gradients, as captured by phase contrast and confocal microscopy

August 2022

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Confocal imaging of 3D biological tissues using the HUMIMIC Chip

Juni 2022

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A confocal laser scanning microscope sheds light on the contribution of TGN/EE SNARE protein SYP61 and ubiquitin ligase ATL31 to C/N-nutrient stress tolerance in plants

Juni 2022

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Digital pathology based on intrinsic fluorescence spectra of liver fibrosis using a multiphoton microscope

Juni 2022

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Reduction of phototoxicity and clarification of fluorescent images by Enhance.ai with high S/N technology using AI

Juni 2022

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Highly accurate and non-invasive cell counts utilizing machine learning

Juni 2022

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SHG imaging and quantitative analysis of bone collagen fibers using a multiphoton microscope

Juni 2022

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High Resolution Confocal Imaging that Accurately Captures Localization of Synapse Region in Cultured Neurons

Juni 2022

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Macro to micro skeletal muscle fiber formation mechanism captured with large FOV confocal microscope

April 2022

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Digital Staining for Cell-Cycle Analysis through a Combination of Fucci and NIS.ai.

April 2022

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The Effects of Refractive Index Mismatch Between Immersion Liquid and Tissue Clearing Reagent on Image Resolution in Deep Areas

April 2022

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Hepatotoxicity test of drug-induced lipidosis using high-content imaging

März 2022

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Validation of control cells in phenotypic screening and selection of analysis methods according to cell morphology

März 2022

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Cell cycle analysis of keratinocytes and label-free cell counting of mitotic cells using Volume Contrast

März 2022

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Ecology of a fossilized cockroach in amber was revealed by confocal microscopy and thin sectioning technology

Februar 2022

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Confocal Imaging of CAR-T Cell Dynamics Using an Organ-on-a-chip Platform

Februar 2022

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Quantitative analysis of lesions of renal foot processes and mitochondria, reusing optical microscopy specimens for clinical renal biopsies, made possible by structured illumination

Januar 2022

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Automatic morphometric extraction of the rabbit osteocytic lacunae using Segment.ai

Dezember 2021

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Morphogenesis imaging of mCherry-expressing Magnaporthe oryzae transformants with DIC and confocal microscopy

Dezember 2021

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High-speed, high-resolution 3D imaging using resonant scanner and Denoise.ai

November 2021

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High-Definition Imaging of Mouse Neuromuscular Junction Using a Resonant Scanner

November 2021

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Localization analysis of RNA polymerase I using a super-resolution microscope and cluster analysis function

November 2021

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3D enhanced resolution confocal imaging of cortical excitatory mouse neurons uncovers dendritic spinule subsets differing in dynamics, regulation, and function

November 2021

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Low Phototoxicity Long-Term Live Cell Apoptosis Assay Using Label-free Live Cell Imaging

November 2021

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Efficient Confocal Imaging of Dynamics and Changes of Cells utilizing a Large Field of View

November 2021

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In vivo Confocal Imaging of Mouse Organs that Clearly Captures Fast Dynamics

November 2021

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Cell Proliferation Assay and Optimization of HCA Assay, Using Label-Free Live Cell Imaging

September 2021

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The Advantages of Resonant Scanning with Ultra Short Laser Exposure Times in Live Imaging

August 2021

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Development of Technology to Visualize Interaction of Osteoblasts and Osteoclasts in Living Bone Tissue

August 2021

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Super-resolution Imaging of the Nanoscale Architecture of Sertoli Cell Cortical F-actin Network

August 2021

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Wide FOV, High-Resolution Confocal Imaging of Podosomes in Osteoclasts ~ Macro and micro observation ~

Juli 2021

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Localization Imaging of HORMAD Proteins and Meiotic Cohesins

Juli 2021

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Selecting the Right Objectives - Bright, Sharp Imaging of Structures down to Deep Areas

Juni 2021

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3D Imaging of Intestinal Organoid

Juni 2021

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Quantitative analysis of mitochondrial morphology over time using AI

April 2021

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AI + Macro Imaging

März 2021

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Quantitative 3D Imaging of Living Organs-on-Chips with a High-Speed Point-Scanning Confocal System

Januar 2021

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Live Imaging of Paneth Cell Secretory Responses in Innate Immunity by Using Three-Dimensional Culture of Small Intestinal Epithelial Cells

Januar 2021

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Super-resolution imaging of double-stained neurons using DNA-Paint

Oktober 2020

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3D Super-resolution imaging of localization of H3K27me3, Lamin AC and DNA

Oktober 2020

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The Secret Inside Flowers - Imaging Inside Plants Using ClearSee Clearing Reagent

Oktober 2020

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Highly accurate segmentation of cell areas based on DIC images using deep learning

September 2020

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Visualization of microglia-neuron junctions with super-resolution and confocal microscopy

Juli 2020

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Imaging sodium transients in neurons and astrocytes

Mai 2020

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Mapping brain cell types with CARTANA in situ sequencing on the Nikon Ti2-E microscope

Januar 2020

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Nikon NIS-Elements Denoise.ai Software: utilizing deep learning to denoise confocal data

Januar 2020

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Ti2: Increasing data collection and fidelity by maximizing field of view

September 2019

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Measuring individual hPSC colony areas using hPSC Colony Area Package

Juni 2019

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A1R HD25: the latest in resonant scanning technology allows new live-cell imaging approaches

Februar 2019

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Increasing Data Collection and Fidelity by Maximizing Confocal Field of View

November 2018

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Structured Illumination Microscopy (SIM) Imaging Comparison with Confocal

September 2018

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Hardware Triggering: Maximizing Speed and Efficiency for Live Cell Imaging

Dezember 2017

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Application of Patterned Illumination Using a DMD for Optogenetic Control of Signaling

November 2017

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Robotic Microscopy with the Nikon Ti2 for High-Content Analysis Applications

Dezember 2016

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N-STORM with DNA-PAINT for Reliable Multicolor & 3D Single Molecule Localization Imaging

November 2016

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N-SIM for Quantitative Ultra-Structural Analyses of the Nuclear Lamina

Oktober 2016

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Quantitative Cluster Analysis Applications for N-STORM

Oktober 2016

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Nikon’s Large-Format Multiphoton System for Intravital Imaging

Dezember 2015

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Quantitative Analysis Tools and Correlative Imaging Applications for N-STORM

November 2015

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Survival Analysis of Human In Vitro-derived Neurons Using New Live Cell Extended Time-lapse Imaging Technology

Juni 2015

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Development of an Integrated Bioprocess for Production of NK-92 Cells for Immunotherapy

Januar 2014

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Antitumor Lymphocyte Kinetic Cytotoxicity Assay (Collaboration with CCRM)

Januar 2013

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A Non-Invasive Method for Counting Human Pluripotent Stem Cell Numbers by Live Cell Imaging

Januar 2012

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Screening Assay for PSC Responses to Substrates

Januar 2011

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Automated Haematopoietic Colony Forming Cell (CFC) Assay

Januar 2011

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Generation of a Growth Curve for iPS Cells in a Feeder-Free Culture by Non-Invasive Image Analysis

Januar 2011

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Establishment of an Algorithm for Automated Detection of iPS/non-iPS Cells Under a Culture Condition by Non-Invasive Image Analysis

Januar 2011

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Automated, Non-Invasive Culture, and Evaluation System for iPS Cells under Neural Differentiation Process

Januar 2011

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Embryonic Stem Cell Responses to Commercially Available Substrates for Stem Cell Maintenance

Januar 2011

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