Note applicative

Confocal imaging of 3D biological tissues using the HUMIMIC Chip

giugno 2022

In this application note, we present an intestinal model, a bone marrow model, and a vascular tissue model cultured in TissUse’s HUMIMIC Chips, which provide a structure that imitates the human body. By visualizing the tissue-specific marker with fluorescence and observing it with a confocal microscope, we confirmed that the tissue created in the chip forms the same structure as the corresponding living tissue. These models have the capability to close the gap between systemic animal models, which are physiological different to human, and standard in vitro assays performed in human derived cells, which cannot reproduce the human physiologic conditions.