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Nikon BioImaging Labs

Nikon BioImaging Labs provide contract research services for microscope-based imaging and analysis to the biotech, pharma, and larger research communities. Each lab's full-service capabilities include access to cutting-edge microscopy instrumentation and software, but also the services of expert biologists and microscopists, who are available to provide quality cell culture, sample preparation, data acquisition, and data analysis services.

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Organ-on-chip Applications

Organ-on-chip models enable the study of multicellular and tissue-level behavior in cells cultured on a scaffold that promotes organ-like conditions and morphology. These platforms are useful for providing a more physiological context to basic research and drug discovery experiments.

We collaborate with manufacturers such as Nortis, TissUse, and Mimetas. Customer-provided devices are welcome.

3D image stack of an angiogenesis model cultured using the OrganoPlate® system (MIMETAS).
Extension of angiogenic sprouting using the idenTx 9 plates(AIM Biotech)

Challenges

Organ-on-chip scaffolds are large, 3D environments. Fully sampling the area of interest can be labor- and data-intensive, and volumetric imaging poses well-known challenges due to optical aberrations.

Solutions

Nikon’s NIS-Elements imaging software provides a powerful toolbox for constructing automated image acquisition and analysis workflows, which improves both the amount and quality of data gathered. Nikon’s vast collection of objective lenses enables high-quality imaging across magnifications and sample types.

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