King's College London

ECLIPSE Ji Smart Imaging System

The ECLIPSE Ji is a fully digital inverted microscope system that combines High Content Screening and research-grade microscopy in a single hardware solution. The Smart Experiment module in NIS-Elements software for Ji can be used for automated High Content Screening using 15+ available assays (endpoint and timelapse). These include assays for cellular morphology, fluorescence intensity measurements, apoptosis analysis, and more. The Ji allows users to capture data with ease – whether tissue sections or culture dishes or multiwell plates. Built-in AI functions to automate tasks like focusing and acquisition parameter optimization.

Upright AX R Multiphoton Gate Stand Point Scanning Confocal

Optimized for deep, gentle, fast intravital imaging, AX R Multiphoton features a gate stand delivering vast space under the objective, large field of view, high speed resonant scanning, with sensitive detectors positioned closest to the sample maximizing signal collection. Equipped with standard visible imaging and NSPARC, this setup achieves significant improvement in resolution and signal-to-noise ratio in both visible and IR imaging.

AX R Confocal with NSPARC detector and ECLIPSE Ti2-E Inverted Microscope

Nikon's AX R confocal features a 25 mm FOV, up to 8192 x 8192 pixel resolution, and is equipped with AI-based tools for simplifying acquisition and analysis. The AX R includes our high definition resonant scanner, which features a next-generation optical non-linear sampling digitizer, supporting imaging at high pixel densities of up to 2048 x 2048, and with superior image quality compared to other currently available resonant scanning systems.

The Nikon Spatial Array Confocal (NSPARC) detector utilizes an ultra-low noise detector array to collect a two-dimensional image at each scanned point. This method of image scanning microscopy (ISM) improves signal-to-noise ratio by increasing the available signal level while simultaneously allowing imaging with lower excitation power.

AX R Confocal with ECLIPSE Ti2-E Inverted Microscope

Nikon's AX R confocal features a 25 mm FOV, up to 8192 x 8192 pixel resolution, and is equipped with AI-based tools for simplifying acquisition and analysis. The AX R includes our high definition resonant scanner, which features a next-generation optical non-linear sampling digitizer, supporting imaging at high pixel densities of up to 2048 x 2048, and with superior image quality compared to other currently available resonant scanning systems.

ECLIPSE Ti2-E Inverted Microscope System with DS-Qi2 and DS50M Camera

The ECLIPSE Ti2-E Inverted research microscope features a groundbreaking 25 mm field of view, maximizing the sensor area of large-format CMOS cameras and significantly improving data throughput. The Ti2-E's unique hardware-triggering capabilities enhance even the most challenging, high-speed imaging applications. Furthermore, the Ti2-E's unique, intelligent functions guide users through imaging workflows by gathering data from internal sensors, eliminating the possibility of user errors. In combination with Nikon's powerful acquisition and analysis software, NIS-Elements, the Ti2 is a total innovation in imaging. This system includes a Nikon DS50M and Qi2 monochrome cameras.

ECLIPSE Ti2-E Inverted Microscope System with DS-Qi2 and DS-Fi2 camera

The ECLIPSE Ti2-E Inverted research microscope features a groundbreaking 25 mm field of view, maximizing the sensor area of large-format CMOS cameras and significantly improving data throughput. The Ti2-E's unique hardware-triggering capabilities enhance even the most challenging, high-speed imaging applications. Furthermore, the Ti2-E's unique, intelligent functions guide users through imaging workflows by gathering data from internal sensors, eliminating the possibility of user errors. In combination with Nikon's powerful acquisition and analysis software, NIS-Elements, the Ti2 is a total innovation in imaging. This system includes a Nikon DS-Fi2 color camera and a monochrome Qi2 camera.

N-STORM/TIRF Super-Resolution System

The N-STORM provides super-resolution single molecule localization imaging on the ECLIPSE Ti2-E inverted microscope. It can reach a resolution of 20 nm laterally, 50 nm axially, and also features live-cell TIRF imaging.

Upright ECLIPSE Ni-E A1R Point Scanning Confocal with 8 slide stage

The ECLIPSE Ni-E A1 laser scanning confocal upright microscope combined with 8 slides stage is perfectly suited for broad range of biological applications particularly high content screening. The A1R confocal is equipped with a unique hybrid scan head incorporating high speed resonant scanner and high-resolution Galvano scanner which can be used in parallel to perform bleaching or photo-activation.

CSU-W1 SoRa Spinning Disk Confocal with ECLIPSE Ti2-E Inverted Microscope

The Nikon CSU-W1 SoRa system combines high-speed, low-phototoxicity confocal imaging with super-resolution capabilities using optical pixel reassignment. Built on the ECLIPSE Ti2 inverted microscope and equipped with a Yokogawa CSU-W1 dual-disk scan head, the system supports both standard confocal and SoRa (Super-resolution via Optical Re-assignment) modes.

In SoRa mode, lateral resolution improves by 1.4X over conventional widefield imaging, and up to 2X with deconvolution—achieving XY resolution down to ~120 nm. The system is ideal for imaging fine subcellular structures in live or fixed samples at depths of 50–100 μm.