Fixed Stage Microscope for Electrophysiological Research

Application Note

Imaging sodium transients in neurons and astrocytes


This application note presents data from Dr Gerkau, Heinrich Heine University, Düsseldorf, Germany on how increases in intracellular sodium in astrocytes and neurons drive the reversal of the sodium/calcium exchange (NCX) during peri-infarct depolarisations (PIDs) in stroke. Nikon’s stable and reliable FN1 microscope combined with its NIS-Elements software were essential in providing high-quality imaging and analysis of intracellular sodium ions in astrocytes and neurons in living brain tissue.