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The Scripps Research Institute

Researchers at The Scripps Research Institute (TSRI) can now probe more deeply and clearly into the microscopic elements of cells with the recent opening of a new Nikon Center of Excellence on the California campus, featuring the latest in advanced imaging technology.

联系方式

CofE Director

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地址

The Scripps Research Institute
Dept. of Molecular and Cellular Neuroscience
10550 N. Torrey Pines Road
DNC 210
La Jolla, CA 92037

Systems Available

AX R Point Scanning Confocal System

This system is equipped with the highly flexible AX R confocal system, which allows for fast, gentle high-resolution imaging of large tissue samples.

Components

8K galvo / 2K resonant imaging modes
ECLIPSE Ti2-E inverted microscope with Perfect Focus System (PFS)
LUA-S4 4-line laser unit (405/488/561/640 nm)
DUX-VB4 spectral detection
NIS-Elements software

A1R Multiphoton Confocal System

Utilizing an open frame design, this multiphoton system is ideal for deep tissue imaging, with galvo and resonance imaging capabilities and the flexibility to integrate in vivo small animal experimental setups.

Components

4K galvo / 1K resonant imaging modes
Open frame upright microscope
Removable ASI XYZ motorized stage
Spectra-Physics Insight X3 Dual IR 1300 nm Laser
LUN4 4-line visible laser unit (405/488/561/640 nm)
Non-descanned detector (NDD)
DU4G descanned detection
NIS-Elements software

ECLIPSE Ti2 Widefield Microscope

This widefield system is equipped with a Tokai Hit incubation chamber, and is ideal for long term imaging in live cell samples.

Components

ECLIPSE Ti2 inverted microscope
Photometrics Iris 15 camera
Tokai Hit incubation chamber
Spectra III light engine

N-STORM/TIRF/A1Rsi Super-Resolution & Confocal System

Featuring both the N-STORM single molecule localization and A1R HD resonant scanning confocal, this system is ready for applications ranging from super-resolution to fast live-cell confocal or TIRF.

Components

Ti-E inverted microscope with Perfect Focus System (PFS)
A1-DUS 32-channel spectral detector
N-STORM super-resolution single molecule localization microscopy system
LU4A 4-line laser unit (405nm, 488nm, 561nm, 638nm)
Mad City Labs Nano-Z series Z-axis piezo stage
DU4 4-channel confocal detector
Andor iXon 897 EMCCD camera
NIS-Elements software

A1Rsi Resonant Scanning Confocal System

Using the Nikon A1Rsi resonant scanning confocal system with spectral detector, this system is made for linear unmixing of multi-labeled samples.

Components

Ti-E inverted microscope with Perfect Focus System (PFS)
A1Rsi resonant scanning confocal system
LUN-4 4-line laser unit (405nm, 488nm, 561nm, 640nm)
A1-DUS 32-channel spectral detector
DU4G GaAsP 4-channel confocal detector
NIS-Elements software

C2 Point Scanning Confocal System

This C2 point-scanning confocal system is configured on a 90i upright microscope and is a great option for applications requiring optical sectioning.

Components

C2 point scanning confocal system
LU4A 4-line laser unit (405nm, 488nm, 561nm, 638nm)
DU3 3-channel confocal detector
NIS-Elements software

A1R Resonant Scanning Confocal System

This A1R resonant scanning confocal system is configured on an FN1 upright microscope, and providing added flexibility for larger samples.

Components

FN1 upright microscope
LUN-4 4-line laser unit (405nm, 488nm, 561nm, 640nm)
DU4G GaAsP 4-channel confocal detector
NIS-Elements software

N-STORM/TIRF Super-Resolution System

While this microscope features the N-STORM localization microscopy system for super-resolution, it can also be operated as a fast live-cell TIRF microscope.

Components

Ti-E inverted microscope with Perfect Focus System (PFS)
N-STORM super-resolution single molecule localization microscopy system
LUN-V 4-line laser unit (405nm, 488nm, 561nm, 647nm)
Mad City Labs Nano-Z series Z-axis piezo stage
Hamamatsu ORCA-Flash4.0 V2+ sCMOS camera
World Precision Instruments AirTherm stage heater
In Vivo Scientific CO2 controller
NIS-Elements software